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On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma.

Publication ,  Journal Article
Liedtke, W; Trübner, K; Schwechheimer, K
Published in: J Neurol Sci
December 1995

Latent infections by human herpesvirus 6 (HHV6) in nervous tissue and its role in human disease are poorly understood. For the present study, an improved PCR method has been applied to brain tissue samples from 5 different brain regions from 20 forensic post-mortem cases without neurologic involvement. Spleen tissue from these cases as well as 5 cerebral lymphoma tissue samples were also examined. HHV6 DNA was detected in 3 of 20 brains. The viral sequences could be amplified from cortical brain tissue from these 3 cases. In one of these cases, HHV6 DNA was detectable in two separate tissue samples. PCR was negative in brain lymphoma and spleen tissue. These findings point toward HHV6 latency in brain tissue and might thus support the reported glial tropism of this virus. No role could be found for HHV6 in the pathogenesis of cerebral lymphoma.

Duke Scholars

Published In

J Neurol Sci

DOI

ISSN

0022-510X

Publication Date

December 1995

Volume

134

Issue

1-2

Start / End Page

184 / 188

Location

Netherlands

Related Subject Headings

  • Virus Latency
  • Molecular Sequence Data
  • Male
  • Lymphoma
  • Humans
  • Herpesvirus 6, Human
  • Female
  • Brain Neoplasms
  • Brain
  • Base Sequence
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liedtke, W., Trübner, K., & Schwechheimer, K. (1995). On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma. J Neurol Sci, 134(1–2), 184–188. https://doi.org/10.1016/0022-510x(95)00248-6
Liedtke, W., K. Trübner, and K. Schwechheimer. “On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma.J Neurol Sci 134, no. 1–2 (December 1995): 184–88. https://doi.org/10.1016/0022-510x(95)00248-6.
Liedtke W, Trübner K, Schwechheimer K. On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma. J Neurol Sci. 1995 Dec;134(1–2):184–8.
Liedtke, W., et al. “On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma.J Neurol Sci, vol. 134, no. 1–2, Dec. 1995, pp. 184–88. Pubmed, doi:10.1016/0022-510x(95)00248-6.
Liedtke W, Trübner K, Schwechheimer K. On the role of human herpesvirus 6 in viral latency in nervous tissue and in cerebral lymphoma. J Neurol Sci. 1995 Dec;134(1–2):184–188.
Journal cover image

Published In

J Neurol Sci

DOI

ISSN

0022-510X

Publication Date

December 1995

Volume

134

Issue

1-2

Start / End Page

184 / 188

Location

Netherlands

Related Subject Headings

  • Virus Latency
  • Molecular Sequence Data
  • Male
  • Lymphoma
  • Humans
  • Herpesvirus 6, Human
  • Female
  • Brain Neoplasms
  • Brain
  • Base Sequence