GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.

Published

Journal Article

To investigate the structural role of glial fibrillary acidic protein (GFAP) in vivo, mice carrying a null mutation in GFAP were generated. In 7/14 mutant animals older than 18 months of age, hydrocephalus associated with white matter loss was detected. Mutant mice displayed abnormal myelination including the presence of actively myelinating oligodendrocytes in adults, nonmyelinated axons in optic nerve, and reduced myelin thickness in spinal cord. White matter was poorly vascularized and the blood-brain barrier was structurally and functionally impaired. Astrocytic structure and function were abnormal, consisting of shortened astrocytic cell processes, decreased septation of white matter, and increased CNS extracellular space. Thus, GFAP expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W; Edelmann, W; Bieri, PL; Chiu, FC; Cowan, NJ; Kucherlapati, R; Raine, CS

Published Date

  • October 1996

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 607 - 615

PubMed ID

  • 8893019

Pubmed Central ID

  • 8893019

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(00)80194-4

Language

  • eng

Conference Location

  • United States