Skip to main content
Journal cover image

GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.

Publication ,  Journal Article
Liedtke, W; Edelmann, W; Bieri, PL; Chiu, FC; Cowan, NJ; Kucherlapati, R; Raine, CS
Published in: Neuron
October 1996

To investigate the structural role of glial fibrillary acidic protein (GFAP) in vivo, mice carrying a null mutation in GFAP were generated. In 7/14 mutant animals older than 18 months of age, hydrocephalus associated with white matter loss was detected. Mutant mice displayed abnormal myelination including the presence of actively myelinating oligodendrocytes in adults, nonmyelinated axons in optic nerve, and reduced myelin thickness in spinal cord. White matter was poorly vascularized and the blood-brain barrier was structurally and functionally impaired. Astrocytic structure and function were abnormal, consisting of shortened astrocytic cell processes, decreased septation of white matter, and increased CNS extracellular space. Thus, GFAP expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

October 1996

Volume

17

Issue

4

Start / End Page

607 / 615

Location

United States

Related Subject Headings

  • Stem Cells
  • Spinal Cord
  • Receptors, Notch
  • Optic Nerve
  • Neurology & Neurosurgery
  • Microscopy, Immunoelectron
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Membrane Glycoproteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liedtke, W., Edelmann, W., Bieri, P. L., Chiu, F. C., Cowan, N. J., Kucherlapati, R., & Raine, C. S. (1996). GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron, 17(4), 607–615. https://doi.org/10.1016/s0896-6273(00)80194-4
Liedtke, W., W. Edelmann, P. L. Bieri, F. C. Chiu, N. J. Cowan, R. Kucherlapati, and C. S. Raine. “GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.Neuron 17, no. 4 (October 1996): 607–15. https://doi.org/10.1016/s0896-6273(00)80194-4.
Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, et al. GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron. 1996 Oct;17(4):607–15.
Liedtke, W., et al. “GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination.Neuron, vol. 17, no. 4, Oct. 1996, pp. 607–15. Pubmed, doi:10.1016/s0896-6273(00)80194-4.
Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, Raine CS. GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron. 1996 Oct;17(4):607–615.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

October 1996

Volume

17

Issue

4

Start / End Page

607 / 615

Location

United States

Related Subject Headings

  • Stem Cells
  • Spinal Cord
  • Receptors, Notch
  • Optic Nerve
  • Neurology & Neurosurgery
  • Microscopy, Immunoelectron
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Membrane Glycoproteins