TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals.

Journal Article (Journal Article;Review)

The TRPV4 ion channel, previously named vanilloid receptor-related osmotically activated channel (VR-OAC), functions in vivo in the transduction of osmotic and mechanical stimuli. In trpv4 null mice, TRPV4 was found to be necessary for the maintenance of systemic osmotic equilibrium, and for normal thresholds in response to noxious mechanical stimuli. In a Caenorhabditis elegans TRPV mutant transgenic for mammalian TRPV4, the mammalian transgene was directing the osmotic and mechanical avoidance response in the context of the ASH 'nociceptive' neurone. Molecular mechanisms of gating of TRPV4 in vivo are not known at this point and have to be determined.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W

Published Date

  • August 15, 2005

Published In

Volume / Issue

  • 567 / Pt 1

Start / End Page

  • 53 - 58

PubMed ID

  • 15961428

Pubmed Central ID

  • PMC1474158

International Standard Serial Number (ISSN)

  • 0022-3751

Digital Object Identifier (DOI)

  • 10.1113/jphysiol.2005.088963


  • eng

Conference Location

  • England