TRPV4 as osmosensor: a transgenic approach.

Published

Journal Article (Review)

The transient receptor potential vanilloid 4 (TRPV4) ion channel was named initially vanilloid-receptor-related osmotically activated channel (VR-OAC). Preliminary answers to the question, "What is the function of the trpv4 gene in live animals ?" are highlighted briefly in this review. In trpv4 null mice, TRPV4 is necessary for the maintenance of osmotic equilibrium, and in Caenorhabditis elegans transgenic for mammalian TRPV4, TRPV4 directs the osmotic avoidance response in the context of the ASH "nociceptive" neuron. The molecular mechanisms of gating of TRPV4 in vivo need to be determined; in particular, whether TRPV4 in live animals is gated via phosphorylation of defined amino-acid residues or more directly through the osmotic stimulus itself.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W

Published Date

  • October 2005

Published In

Volume / Issue

  • 451 / 1

Start / End Page

  • 176 - 180

PubMed ID

  • 15952033

Pubmed Central ID

  • 15952033

International Standard Serial Number (ISSN)

  • 0031-6768

Digital Object Identifier (DOI)

  • 10.1007/s00424-005-1449-8

Language

  • eng

Conference Location

  • Germany