Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli.

Published

Journal Article (Review)

In signal transduction of metazoan cells, ion channels of the family of transient receptor potential (TRP) have been identified to respond to diverse external and internal stimuli, amongst them osmotic stimuli. This review will highlight findings on the TRPV subfamily, both vertebrate and invertebrate members. Out of the six mammalian TRP vanilloid (TRPV) channels, TRPV1, TRPV2, and TRPV4 were demonstrated to function in transduction of osmotic stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue osmo- and mechanosensory deficits of the TRPV mutant strain osm-9 in C. elegans, despite not more than 26% orthology of the respective proteins.

Full Text

Duke Authors

Cited Authors

  • Liedtke, W

Published Date

  • December 2006

Published In

Volume / Issue

  • 191 / 3

Start / End Page

  • 515 - 523

PubMed ID

  • 17170210

Pubmed Central ID

  • 17170210

International Standard Serial Number (ISSN)

  • 0022-0795

Digital Object Identifier (DOI)

  • 10.1677/joe.1.07000

Language

  • eng

Conference Location

  • England