Inhalation exposure system used for acute and repeated-dose methyl isocyanate exposures of laboratory animals.

Journal Article (Journal Article)

Laboratory animals were exposed by inhalation for 2 hr/day (acute) or 6 hr/day (four consecutive days, repeated dose) to methyl isocyanate (MIC). Exposures were conducted in stainless steel and glass inhalation exposure chambers placed in stainless steel, wire mesh cages. MIC was delivered with nitrogen via stainless steel and Teflon supply lines. Chamber concentrations ranged from 0 to 60 ppm and were monitored continuously with infrared spectrophotometers to 1 ppm and at 2-hr intervals to 20 ppb with a high performance liquid chromatograph equipped with a fluorescence detector. Other operational parameters monitored on a continuous basis included chamber temperature (20-27 degrees C), relative humidity (31-64%), static (transmural) pressure (-0.3 in.), and flow (300-500 L/min). The computer-assistance system interfaced with the inhalation exposure laboratory is described in detail, including the analytical instrumentation calibration system used throughout this investigation.

Full Text

Duke Authors

Cited Authors

  • Adkins, B; O'Connor, RW; Dement, JM

Published Date

  • June 1, 1987

Published In

Volume / Issue

  • 72 /

Start / End Page

  • 45 - 51

PubMed ID

  • 3622442

Pubmed Central ID

  • PMC1474654

International Standard Serial Number (ISSN)

  • 0091-6765

Digital Object Identifier (DOI)

  • 10.1289/ehp.877245

Language

  • eng

Conference Location

  • United States