The dehydroepiandrosterone loading test. IV. Evaluation of clinical utility.

Journal Article (Journal Article)

This report complements the previously described preliminary clinical evaluation of the dehydroepiandrosterone (DHEA) loading test (DLT) by presenting the results of 65 DLTs in 59 patients. In patients whose fetuses were suspected of being intrauterine growth retarded, a DHEA to estrogen conversion rate constant less than or equal to 3.0 x 10(-3) min(-1) was associated with a birth weight below the tenth percentile in 60% of the pregnancies, whereas a conversion rate constant above this threshold was not associated with the same degree of growth retardation. The DLT continues to qualify as an accurate predictor of pregnancy outcome as judged by birth weight. Although it seems to be too cumbersome to serve as a screening technique, the DLT will permit evaluation of the efficacy of various pregnancy interventions directed toward improvement of the intrauterine environment, such as bed rest, tocolysis, or antihypertensive medication.

Full Text

Duke Authors

Cited Authors

  • Nagey, DA; Pupkin, MJ; Mandeville, L; Schomberg, DW; Crenshaw, C

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 142 / 1

Start / End Page

  • 60 - 65

PubMed ID

  • 6459738

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/s0002-9378(16)32285-2


  • eng

Conference Location

  • United States