Gonadotropin release in patients with androgen insensitivity. Testicular feminization syndrome.

Journal Article (Journal Article)

Two siblings are presented, both with classic androgen-insensitivity syndrome (AIS). Endocrine testing was carried out and then gonadectomy was performed. Studies in these patients with AIS revealed low control serum FSH. In these patients serum FSH was not significantly suppressed by intravenous estrogen nor adequately stimulated by FSH-LH-releasing hormone but rose normally after castration. The various studies are interpreted in the light of the known kinetics of pituitary gonadotorpins and their modulation by gonadal steroids. A third sibling is also presented.

Full Text

Duke Authors

Cited Authors

  • Addison, WA; Hammond, CB; Tyrey, L; Schomberg, DW

Published Date

  • March 1, 1976

Published In

Volume / Issue

  • 47 / 3

Start / End Page

  • 331 - 336

PubMed ID

  • 765906

International Standard Serial Number (ISSN)

  • 0029-7844


  • eng

Conference Location

  • United States