Platelet-derived growth factor enhances granulosa cell luteinizing hormone receptor induction by follicle-stimulating hormone and serum.

Journal Article (Journal Article)

Platelet-derived growth factor potentiated FSH-dependent LH receptor induction in serum-free and serum-containing cultures of rat granulosa cells. Levels of LH receptor binding comparable to pre-ovulatory levels could be achieved in vitro using a combination of FSH, platelet-derived growth factor, and serum. Receptor sites induced under these conditions were capable of mediating an hCG-stimulated increase in progestin secretion. Our results in vitro suggest a possible role for platelet-derived growth factor or related compounds in granulosa cell differentiation in vivo.

Full Text

Duke Authors

Cited Authors

  • Mondschein, JS; Schomberg, DW

Published Date

  • July 1981

Published In

Volume / Issue

  • 109 / 1

Start / End Page

  • 325 - 327

PubMed ID

  • 6263591

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/endo-109-1-325


  • eng

Conference Location

  • United States