Steroidal modulation of steroid secretion in vitro: an experimental approach to intra-follicular regulatory mechanisms.

Journal Article (Journal Article;Review)

Studies in vitro and in vivo indicate that steroid secretion by granulosa cells of the developing follicle is modulated in part by steroid hormones themselves. Androgens stimulate progestin synthesis in vitro by granulosa cells of all developmental stages independently of their role as an estrogen precursor; generally, the action of estradiol results in suppression of progesterone secretion. The nature of the relationship between steroid secretion by granulosa cells and the physiological processes of follicular development or atresia remains to be investigated in greater detail. The cellular mechanism(s) of steroidal modulation of steroid secretion is unknown but apparently does not involve changes in the number of granulosa cell LH receptors per se.

Full Text

Duke Authors

Cited Authors

  • Schomberg, DW

Published Date

  • 1979

Published In

Volume / Issue

  • 112 /

Start / End Page

  • 155 - 168

PubMed ID

  • 223385

International Standard Serial Number (ISSN)

  • 0065-2598

Digital Object Identifier (DOI)

  • 10.1007/978-1-4684-3474-3_19


  • eng

Conference Location

  • United States