Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.

Journal Article (Journal Article)

Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat. In contrast, platelet-derived growth factor potentiated the induction of luteinizing hormone receptor by follicle-stimulating hormone. These results indicate that growth factors, well known for their effects on mitosis and DNA synthesis in cultured mammalian cells, are also able to modulate hormone-dependent differentiation in an endocrine target cell.

Full Text

Duke Authors

Cited Authors

  • Mondschein, JS; Schomberg, DW

Published Date

  • March 13, 1981

Published In

Volume / Issue

  • 211 / 4487

Start / End Page

  • 1179 - 1180

PubMed ID

  • 6258228

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6258228


  • eng

Conference Location

  • United States