Growth factors modulate gonadotropin receptor induction in granulosa cell cultures.
Journal Article (Journal Article)
Epidermal growth factor and fibroblast growth factor inhibited follicle-stimulating hormone-dependent induction of luteinizing hormone receptor in cultured ovarian granulosa cells of the rat. In contrast, platelet-derived growth factor potentiated the induction of luteinizing hormone receptor by follicle-stimulating hormone. These results indicate that growth factors, well known for their effects on mitosis and DNA synthesis in cultured mammalian cells, are also able to modulate hormone-dependent differentiation in an endocrine target cell.
- Mondschein, JS; Schomberg, DW
- March 13, 1981
Volume / Issue
- 211 / 4487
Start / End Page
- 1179 - 1180
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States