Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.

Journal Article (Journal Article)

Intra-ovarian Silastic implants containing the antiandrogen, Flutamide, or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis during follicular development.

Full Text

Duke Authors

Cited Authors

  • Schomberg, DW; Williams, RF; Tyrey, L; Ulberg, LC

Published Date

  • March 1, 1978

Published In

Volume / Issue

  • 102 / 3

Start / End Page

  • 984 - 987

PubMed ID

  • 744003

International Standard Serial Number (ISSN)

  • 0013-7227

Digital Object Identifier (DOI)

  • 10.1210/endo-102-3-984


  • eng

Conference Location

  • United States