Reduction of granulosa cell progesterone secretion in vitro by intraovarian implants of antiandrogen.
Intra-ovarian Silastic implants containing the antiandrogen, Flutamide, or its active metabolite, reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis during follicular development.
Schomberg, DW; Williams, RF; Tyrey, L; Ulberg, LC
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