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Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age.

Publication ,  Journal Article
Hiett, AK; Britton, KA; Hague, NL; Brown, HL; Stehman, FB; Broxmeyer, HE
Published in: Transfusion
July 1995

BACKGROUND: Cord blood has been used for transplantation. The purpose of this study was to compare numbers of hematopoietic progenitors in cord blood collected from neonatal infants who are small for their gestational age and those who are normal. STUDY DESIGN AND METHODS: Sixteen pregnant women diagnosed with intrauterine growth restriction were prospectively identified. Cord blood was collected at delivery. Fourteen cord blood samples were obtained from gestational age-matched, appropriately grown newborns. In vitro assays for hematopoietic progenitors were performed and results of the two compared. Comparisons were also made with numbers of hematopoietic progenitor cells previously found by this laboratory in samples collected with the possibility of use for transplantation. RESULTS: Gestational age, the women's pregnancy and delivery histories, maternal risk factors for intrauterine growth restriction, maternal age, delivery method, umbilical cord blood gases, and 5-minute Apgar scores were similar in the two groups. Newborns who were small for their gestational age had significantly lower birth weights and longer stays in the neonatal intensive care unit with no evidence for viral infections in the immediate neonatal period. The mean number of progenitors per collection of cord blood in the small newborns was about half that per collection from appropriately grown newborns, but in most cases, these differences were not significant in the two groups, and many numbers in the small newborns fell within the range associated with successfully engrafting cord blood collections. CONCLUSION: Hematopoietic progenitor cells in the small newborns may be adequate for transplantation purposes in many cases. Their possible use in this context should, however, involve careful consideration of the numbers of progenitors collected as well as of possible viral or other contamination.

Duke Scholars

Published In

Transfusion

DOI

ISSN

0041-1132

Publication Date

July 1995

Volume

35

Issue

7

Start / End Page

587 / 591

Location

United States

Related Subject Headings

  • Pregnancy
  • Infant, Small for Gestational Age
  • Infant, Newborn
  • Humans
  • Hematopoietic Stem Cells
  • Fetal Blood
  • Female
  • Colony-Forming Units Assay
  • Cell Differentiation
  • Cell Count
 

Citation

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Chicago
ICMJE
MLA
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Hiett, A. K., Britton, K. A., Hague, N. L., Brown, H. L., Stehman, F. B., & Broxmeyer, H. E. (1995). Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age. Transfusion, 35(7), 587–591. https://doi.org/10.1046/j.1537-2995.1995.35795357882.x
Hiett, A. K., K. A. Britton, N. L. Hague, H. L. Brown, F. B. Stehman, and H. E. Broxmeyer. “Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age.Transfusion 35, no. 7 (July 1995): 587–91. https://doi.org/10.1046/j.1537-2995.1995.35795357882.x.
Hiett AK, Britton KA, Hague NL, Brown HL, Stehman FB, Broxmeyer HE. Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age. Transfusion. 1995 Jul;35(7):587–91.
Hiett, A. K., et al. “Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age.Transfusion, vol. 35, no. 7, July 1995, pp. 587–91. Pubmed, doi:10.1046/j.1537-2995.1995.35795357882.x.
Hiett AK, Britton KA, Hague NL, Brown HL, Stehman FB, Broxmeyer HE. Comparison of hematopoietic progenitor cells in human umbilical cord blood collected from neonatal infants who are small and appropriate for gestational age. Transfusion. 1995 Jul;35(7):587–591.
Journal cover image

Published In

Transfusion

DOI

ISSN

0041-1132

Publication Date

July 1995

Volume

35

Issue

7

Start / End Page

587 / 591

Location

United States

Related Subject Headings

  • Pregnancy
  • Infant, Small for Gestational Age
  • Infant, Newborn
  • Humans
  • Hematopoietic Stem Cells
  • Fetal Blood
  • Female
  • Colony-Forming Units Assay
  • Cell Differentiation
  • Cell Count