Localization of age-associated white matter hyperintensities in late-life depression.

Journal Article (Journal Article)

OBJECTIVE: Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects. METHODS: Eighty-seven depressed subjects and 47 control subjects underwent 1.5 T cranial magnetic resonance imaging (MRI). Utilizing a semiautomated method, a segmented image was created containing only white matter lesions. We created a statistical parametric map (SPM) separately for each subject group that displayed the association between lesions in any voxel and advanced age. RESULTS: The SPM analysis in depressed subjects demonstrates a significant association between age and lesions found in bilateral, frontal, and left parietal regions. The analysis in control subjects found significant associations only in bilateral parieto-temporal regions, not frontal regions. CONCLUSIONS: This study demonstrates a different pattern of age-related lesion location between depressed and control subjects. It further supports the theory that frontostriatal disconnection contributes to late-life depression.

Full Text

Duke Authors

Cited Authors

  • Taylor, WD; MacFall, JR; Steffens, DC; Payne, ME; Provenzale, JM; Krishnan, KRR

Published Date

  • May 2003

Published In

Volume / Issue

  • 27 / 3

Start / End Page

  • 539 - 544

PubMed ID

  • 12691791

International Standard Serial Number (ISSN)

  • 0278-5846

Digital Object Identifier (DOI)

  • 10.1016/S0278-5846(02)00358-5


  • eng

Conference Location

  • England