Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.

Journal Article (Journal Article;Review)

Whether or not severe febrile seizures in infancy cause hippocampal injury and subsequent medial temporal sclerosis is an often debated question in epilepsy. Recent magnetic resonance imaging (MRI) of infants suffering from febrile seizures has provided preliminary evidence that abnormally increased T2 signal intensity can be seen in the hippocampi of infants following prolonged and focal febrile seizures. Follow-up MRIs in a few of these infants have confirmed that medial temporal sclerosis can develop following these acute MRI signal changes. In this article, we review the hypotheses and MRI evidence relating to hippocampal injury during prolonged febrile seizures and the later development of medial temporal sclerosis.

Full Text

Duke Authors

Cited Authors

  • Lewis, DV; Barboriak, DP; MacFall, JR; Provenzale, JM; Mitchell, TV; VanLandingham, KE

Published Date

  • 2002

Published In

Volume / Issue

  • 135 /

Start / End Page

  • 263 - 278

PubMed ID

  • 12143347

International Standard Serial Number (ISSN)

  • 0079-6123

Digital Object Identifier (DOI)

  • 10.1016/s0079-6123(02)35025-8


  • eng

Conference Location

  • Netherlands