The role of blood-brain barrier permeability in brain tumor imaging and therapeutics.

Journal Article (Journal Article;Review)

OBJECTIVE: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes. CONCLUSION: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.

Full Text

Duke Authors

Cited Authors

  • Provenzale, JM; Mukundan, S; Dewhirst, M

Published Date

  • September 2005

Published In

Volume / Issue

  • 185 / 3

Start / End Page

  • 763 - 767

PubMed ID

  • 16120931

International Standard Serial Number (ISSN)

  • 0361-803X

Digital Object Identifier (DOI)

  • 10.2214/ajr.185.3.01850763


  • eng

Conference Location

  • United States