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Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke.

Publication ,  Journal Article
Eastwood, JD; Lev, MH; Wintermark, M; Fitzek, C; Barboriak, DP; Delong, DM; Lee, T-Y; Azhari, T; Herzau, M; Chilukuri, VR; Provenzale, JM
Published in: AJNR Am J Neuroradiol
October 2003

BACKGROUND AND PURPOSE: Compared with MR imaging, dynamic CT perfusion imaging covers only a fraction of the whole brain. An important assumption is that CT perfusion abnormalities correlate with total ischemic volume. The purpose of our study was to measure the degree of correlation between abnormalities seen on CT perfusion scans and the volumes of abnormality seen on MR diffusion and perfusion images in patients with acute large-vessel stroke. METHODS: Fourteen patients with acute hemispheric stroke symptoms less than 12 hours in duration were studied with single-slice CT perfusion imaging and multislice MR diffusion and perfusion imaging. CT and MR perfusion studies were completed within 2.5 hours of one another (mean, 77 minutes) and were reviewed independently by two neuroradiologists. Hemodynamic parameters included cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT). Extents of abnormality on images were compared by using Kendall correlation. RESULTS: Statistically significant correlation was found between CT-CBF and MR-CBF abnormalities (tau = 0.60, P =.003) and CT-MTT and MR-MTT abnormalities (tau = 0.65, P =.001). Correlation of CT-CBV with MR-CBV approached significance (tau = 0.39, P =.06). Extent of initial hyperintensity on diffusion-weighted images correlated best with extent of MR-CBV abnormality (tau = 0.69, P =.001), extent of MR-MTT abnormality (tau = 0.67, P =.002), and extent of CT-CBV abnormality (tau = 0.47, P =.02). CONCLUSION: Good correlation was seen between CT and MR for CBF and MTT abnormalities. It remains uncertain whether CT perfusion CBV abnormalities correspond well to whole-brain abnormalities.

Duke Scholars

Published In

AJNR Am J Neuroradiol

ISSN

0195-6108

Publication Date

October 2003

Volume

24

Issue

9

Start / End Page

1869 / 1875

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Stroke
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Humans
  • Female
  • Diffusion Magnetic Resonance Imaging
  • Contrast Media
 

Citation

APA
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ICMJE
MLA
NLM
Eastwood, J. D., Lev, M. H., Wintermark, M., Fitzek, C., Barboriak, D. P., Delong, D. M., … Provenzale, J. M. (2003). Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke. AJNR Am J Neuroradiol, 24(9), 1869–1875.
Eastwood, James D., Michael H. Lev, Max Wintermark, Clemens Fitzek, Daniel P. Barboriak, David M. Delong, Ting-Yim Lee, et al. “Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke.AJNR Am J Neuroradiol 24, no. 9 (October 2003): 1869–75.
Eastwood JD, Lev MH, Wintermark M, Fitzek C, Barboriak DP, Delong DM, et al. Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke. AJNR Am J Neuroradiol. 2003 Oct;24(9):1869–75.
Eastwood, James D., et al. “Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke.AJNR Am J Neuroradiol, vol. 24, no. 9, Oct. 2003, pp. 1869–75.
Eastwood JD, Lev MH, Wintermark M, Fitzek C, Barboriak DP, Delong DM, Lee T-Y, Azhari T, Herzau M, Chilukuri VR, Provenzale JM. Correlation of early dynamic CT perfusion imaging with whole-brain MR diffusion and perfusion imaging in acute hemispheric stroke. AJNR Am J Neuroradiol. 2003 Oct;24(9):1869–1875.

Published In

AJNR Am J Neuroradiol

ISSN

0195-6108

Publication Date

October 2003

Volume

24

Issue

9

Start / End Page

1869 / 1875

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Stroke
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Humans
  • Female
  • Diffusion Magnetic Resonance Imaging
  • Contrast Media