Multiple gamma c-dependent cytokines regulate T-cell development.

Journal Article (Journal Article;Review)

Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development.

Full Text

Duke Authors

Cited Authors

  • Malek, TR; Porter, BO; He, YW

Published Date

  • February 1999

Published In

Volume / Issue

  • 20 / 2

Start / End Page

  • 71 - 76

PubMed ID

  • 10098325

International Standard Serial Number (ISSN)

  • 0167-5699

Digital Object Identifier (DOI)

  • 10.1016/s0167-5699(98)01391-7


  • eng

Conference Location

  • England