Correlating notch signaling with thymocyte maturation.

Journal Article (Journal Article)

The Notch receptor and its ligands are involved in many developmental processes. They are highly expressed in the thymus and have been implicated in the CD4 versus CD8 lineage decision. We identified the constitutively active intracellular fragment of murine Notch-1 as capable of rendering thymomas resistant to glucocorticoid-induced apoptosis. This effect was confirmed in other T cell lines and in CD4+ CD8+ DP thymocytes. Activation of the Notch signaling pathway also upregulated a number of other markers that, like steroid resistance, correlate with DP maturation into both the CD4 and CD8 lineages. These results suggest that Notch signaling is critically involved in the maturation of DP thymocytes into both CD4+ and CD8+ SP thymocytes.

Full Text

Duke Authors

Cited Authors

  • Deftos, ML; He, YW; Ojala, EW; Bevan, MJ

Published Date

  • December 1998

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 777 - 786

PubMed ID

  • 9881968

Pubmed Central ID

  • PMC2789684

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)80643-3


  • eng

Conference Location

  • United States