Correlating notch signaling with thymocyte maturation.
Journal Article (Journal Article)
The Notch receptor and its ligands are involved in many developmental processes. They are highly expressed in the thymus and have been implicated in the CD4 versus CD8 lineage decision. We identified the constitutively active intracellular fragment of murine Notch-1 as capable of rendering thymomas resistant to glucocorticoid-induced apoptosis. This effect was confirmed in other T cell lines and in CD4+ CD8+ DP thymocytes. Activation of the Notch signaling pathway also upregulated a number of other markers that, like steroid resistance, correlate with DP maturation into both the CD4 and CD8 lineages. These results suggest that Notch signaling is critically involved in the maturation of DP thymocytes into both CD4+ and CD8+ SP thymocytes.
Full Text
Duke Authors
Cited Authors
- Deftos, ML; He, YW; Ojala, EW; Bevan, MJ
Published Date
- December 1998
Published In
Volume / Issue
- 9 / 6
Start / End Page
- 777 - 786
PubMed ID
- 9881968
Pubmed Central ID
- PMC2789684
International Standard Serial Number (ISSN)
- 1074-7613
Digital Object Identifier (DOI)
- 10.1016/s1074-7613(00)80643-3
Language
- eng
Conference Location
- United States