RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.
We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. Following hybridoma stimulation, RORgamma t also inhibits IL-2 production but does not affect the induction of Nur-77 and Egr-3 nor the upregulation of CD69. Both the ligand-binding and DNA-binding domains of RORgamma t are required for this effect. We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection.
Duke Scholars
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- Tumor Cells, Cultured
- T-Lymphocytes
- Receptors, Thyroid Hormone
- Receptors, Retinoic Acid
- Receptors, Cytoplasmic and Nuclear
- Receptor-CD3 Complex, Antigen, T-Cell
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Molecular Sequence Data
- Mice, Inbred C57BL
- Mice
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Cells, Cultured
- T-Lymphocytes
- Receptors, Thyroid Hormone
- Receptors, Retinoic Acid
- Receptors, Cytoplasmic and Nuclear
- Receptor-CD3 Complex, Antigen, T-Cell
- Nuclear Receptor Subfamily 1, Group F, Member 3
- Molecular Sequence Data
- Mice, Inbred C57BL
- Mice