RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.

Published

Journal Article

We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. Following hybridoma stimulation, RORgamma t also inhibits IL-2 production but does not affect the induction of Nur-77 and Egr-3 nor the upregulation of CD69. Both the ligand-binding and DNA-binding domains of RORgamma t are required for this effect. We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection.

Full Text

Duke Authors

Cited Authors

  • He, YW; Deftos, ML; Ojala, EW; Bevan, MJ

Published Date

  • December 1998

Published In

Volume / Issue

  • 9 / 6

Start / End Page

  • 797 - 806

PubMed ID

  • 9881970

Pubmed Central ID

  • 9881970

International Standard Serial Number (ISSN)

  • 1074-7613

Language

  • eng

Conference Location

  • United States