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RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.

Publication ,  Journal Article
He, YW; Deftos, ML; Ojala, EW; Bevan, MJ
Published in: Immunity
December 1998

We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. Following hybridoma stimulation, RORgamma t also inhibits IL-2 production but does not affect the induction of Nur-77 and Egr-3 nor the upregulation of CD69. Both the ligand-binding and DNA-binding domains of RORgamma t are required for this effect. We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection.

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Published In

Immunity

DOI

ISSN

1074-7613

Publication Date

December 1998

Volume

9

Issue

6

Start / End Page

797 / 806

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocytes
  • Receptors, Thyroid Hormone
  • Receptors, Retinoic Acid
  • Receptors, Cytoplasmic and Nuclear
  • Receptor-CD3 Complex, Antigen, T-Cell
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice
 

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He, Y. W., Deftos, M. L., Ojala, E. W., & Bevan, M. J. (1998). RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity, 9(6), 797–806. https://doi.org/10.1016/s1074-7613(00)80645-7
He, Y. W., M. L. Deftos, E. W. Ojala, and M. J. Bevan. “RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.Immunity 9, no. 6 (December 1998): 797–806. https://doi.org/10.1016/s1074-7613(00)80645-7.
He, Y. W., et al. “RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.Immunity, vol. 9, no. 6, Dec. 1998, pp. 797–806. Pubmed, doi:10.1016/s1074-7613(00)80645-7.
Journal cover image

Published In

Immunity

DOI

ISSN

1074-7613

Publication Date

December 1998

Volume

9

Issue

6

Start / End Page

797 / 806

Location

United States

Related Subject Headings

  • Tumor Cells, Cultured
  • T-Lymphocytes
  • Receptors, Thyroid Hormone
  • Receptors, Retinoic Acid
  • Receptors, Cytoplasmic and Nuclear
  • Receptor-CD3 Complex, Antigen, T-Cell
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice