The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development.


Journal Article (Review)

T lymphocytes differentiate in the thymus through several phenotypically distinct stages that are tightly regulated by multiple nuclear transcription factors. Immature CD4+CD8+ double positive (DP) thymocytes make up a majority of the population in the thymus, and exhibit several phenotypic features distinct from mature T cells. DP thymocytes express only about 10% of surface TCR that are found on mature T cells and do not proliferate and produce IL-2 in response to stimulation. Several critical events of T lymphocyte maturation such as TCRalpha gene recombination, positive and negative selection, and CD4/CD8 lineage commitment occur around the DP stage. Recent studies from our group and others on the orphan nuclear receptor RORgamma and its thymus-specific isoform RORgammat support a critical role for this nuclear receptor in the regulation of DP thymocyte function. In addition, RORgamma is required for the development of lymph nodes and Peyer's patches.

Full Text

Duke Authors

Cited Authors

  • He, YW

Published Date

  • 2000

Published In

Volume / Issue

  • 22 / 2-3

Start / End Page

  • 71 - 82

PubMed ID

  • 11339367

Pubmed Central ID

  • 11339367

International Standard Serial Number (ISSN)

  • 0257-277X

Digital Object Identifier (DOI)

  • 10.1385/IR:22:2-3:71


  • eng

Conference Location

  • United States