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The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development.

Publication ,  Journal Article
He, YW
Published in: Immunol Res
2000

T lymphocytes differentiate in the thymus through several phenotypically distinct stages that are tightly regulated by multiple nuclear transcription factors. Immature CD4+CD8+ double positive (DP) thymocytes make up a majority of the population in the thymus, and exhibit several phenotypic features distinct from mature T cells. DP thymocytes express only about 10% of surface TCR that are found on mature T cells and do not proliferate and produce IL-2 in response to stimulation. Several critical events of T lymphocyte maturation such as TCRalpha gene recombination, positive and negative selection, and CD4/CD8 lineage commitment occur around the DP stage. Recent studies from our group and others on the orphan nuclear receptor RORgamma and its thymus-specific isoform RORgammat support a critical role for this nuclear receptor in the regulation of DP thymocyte function. In addition, RORgamma is required for the development of lymph nodes and Peyer's patches.

Duke Scholars

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2000

Volume

22

Issue

2-3

Start / End Page

71 / 82

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Thyroid Hormone
  • Receptors, Retinoic Acid
  • Receptors, Cytoplasmic and Nuclear
  • Peyer's Patches
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Lymph Nodes
  • Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
He, Y. W. (2000). The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development. Immunol Res, 22(2–3), 71–82. https://doi.org/10.1385/IR:22:2-3:71
He, Y. W. “The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development.Immunol Res 22, no. 2–3 (2000): 71–82. https://doi.org/10.1385/IR:22:2-3:71.
He, Y. W. “The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development.Immunol Res, vol. 22, no. 2–3, 2000, pp. 71–82. Pubmed, doi:10.1385/IR:22:2-3:71.
Journal cover image

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2000

Volume

22

Issue

2-3

Start / End Page

71 / 82

Location

United States

Related Subject Headings

  • Transcription, Genetic
  • Thymus Gland
  • T-Lymphocytes
  • Receptors, Thyroid Hormone
  • Receptors, Retinoic Acid
  • Receptors, Cytoplasmic and Nuclear
  • Peyer's Patches
  • Nuclear Receptor Subfamily 1, Group F, Member 3
  • Lymph Nodes
  • Immunology