Interleukin-7 receptor alpha is essential for the development of gamma delta + T cells, but not natural killer cells.

Published

Journal Article

Mice that lack a functional gamma c subunit of the receptors for interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 display profound defects in lymphoid development. The IL-7/IL-7R system represents a critical interaction for conventional T and B cell development. In this report, the role of IL-7R alpha in the development of lymphoid lineages other than conventional T and B cells was examined. We demonstrate that gamma delta + T cells were absent in IL-7R alpha-deficient mice, whereas the development and function of natural killer cells were normal. Thus, IL-7R alpha function is required for the development of gamma delta + T cells but not natural killer cells.

Full Text

Duke Authors

Cited Authors

  • He, YW; Malek, TR

Published Date

  • July 1, 1996

Published In

Volume / Issue

  • 184 / 1

Start / End Page

  • 289 - 293

PubMed ID

  • 8691145

Pubmed Central ID

  • 8691145

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.184.1.289

Language

  • eng

Conference Location

  • United States