A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice.

Published

Journal Article

Radiolabeled alpha 2-antiplasmin cleared slowly from the circulation of mice. Complex formation with either plasmin or trypsin resulted in a significant increase in the plasma elimination rate of the protease inhibitor. Approximately 20 min and 14 min were required for 50% of the injected alpha 2-antiplasmin-plasmin and alpha 2-antiplasmin-trypsin to clear from the circulation, respectively. Significant competition was observed when radiolabeled alpha 2-antiplasmin-plasmin was cleared in the presence of a large molar excess of unlabeled alpha 2-antiplasmin-plasmin. alpha 1-Antitrypsin-trypsin failed to complete with radiolabeled alpha 2-antiplasmin-plasmin even when present at 2000 fold molar excess. Organ distribution studies localized the major site of alpha 2-antiplasmin-plasmin clearance in the liver. Microscopic autoradiography data suggested that the cell responsible for the clearance pathway was the hepatocyte.

Full Text

Duke Authors

Cited Authors

  • Gonias, SL; Fuchs, HE; Pizzo, SV

Published Date

  • October 29, 1982

Published In

Volume / Issue

  • 48 / 2

Start / End Page

  • 208 - 210

PubMed ID

  • 6758181

Pubmed Central ID

  • 6758181

International Standard Serial Number (ISSN)

  • 0340-6245

Language

  • eng

Conference Location

  • Germany