Prevention and treatment of nosocomial sepsis in the NICU.

Journal Article (Journal Article;Review)

Nosocomial sepsis is a serious problem for neonates who are admitted for intensive care. It is associated with an increase in mortality, morbidity, and prolonged length of hospital stay. Thus, both the human and fiscal costs of these infections are high. Although the rate of nosocomial sepsis increases with the degree of both prematurity and low birth weight, no specific lab test has been shown to be very useful in improving our ability to predict who has a "real" blood-stream infection and, therefore, who needs to be treated with a full course of antibiotics. As a result, antibiotic use is double the rate of "proven" sepsis and we are facilitating the growth of resistant organisms in the neonatal intensive care unit. The purpose of this article is to describe simple changes in process, which when implemented, can reduce nosocomial infection rates in neonates and improve outcomes.

Full Text

Duke Authors

Cited Authors

  • Clark, R; Powers, R; White, R; Bloom, B; Sanchez, P; Benjamin, DK

Published Date

  • July 1, 2004

Published In

Volume / Issue

  • 24 / 7

Start / End Page

  • 446 - 453

PubMed ID

  • 15129228

International Standard Serial Number (ISSN)

  • 0743-8346

Digital Object Identifier (DOI)

  • 10.1038/


  • eng

Conference Location

  • United States