In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.
The activity of albaconazole (UR-9825; J. Uriach & Cía. S.A., Barcelona, Spain) was compared to that of fluconazole against 12 isolates of Cryptococcus neoformans in vitro and against 1 isolate in vivo in a rabbit model of cryptococcal meningitis. Albaconazole was 100-fold more potent in vitro than fluconazole on a per-weight basis and was fungicidal at potentially relevant concentrations for two isolates. MICs ranged from
Miller, JL; Schell, WA; Wills, EA; Toffaletti, DL; Boyce, M; Benjamin, DK; Bartroli, J; Perfect, JR
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