In vitro and in vivo efficacies of the new triazole albaconazole against Cryptococcus neoformans.

Journal Article (Journal Article)

The activity of albaconazole (UR-9825; J. Uriach & Cía. S.A., Barcelona, Spain) was compared to that of fluconazole against 12 isolates of Cryptococcus neoformans in vitro and against 1 isolate in vivo in a rabbit model of cryptococcal meningitis. Albaconazole was 100-fold more potent in vitro than fluconazole on a per-weight basis and was fungicidal at potentially relevant concentrations for two isolates. MICs ranged from

Full Text

Duke Authors

Cited Authors

  • Miller, JL; Schell, WA; Wills, EA; Toffaletti, DL; Boyce, M; Benjamin, DK; Bartroli, J; Perfect, JR

Published Date

  • February 2004

Published In

Volume / Issue

  • 48 / 2

Start / End Page

  • 384 - 387

PubMed ID

  • 14742184

Pubmed Central ID

  • PMC321550

International Standard Serial Number (ISSN)

  • 0066-4804

Digital Object Identifier (DOI)

  • 10.1128/AAC.48.2.384-387.2004


  • eng

Conference Location

  • United States