Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.
Journal Article (Journal Article)
Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.
Full Text
Duke Authors
Cited Authors
- Meador, WE; Means, AR; Quiocho, FA
Published Date
- December 10, 1993
Published In
Volume / Issue
- 262 / 5140
Start / End Page
- 1718 - 1721
PubMed ID
- 8259515
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.8259515
Language
- eng
Conference Location
- United States