Modulation of calmodulin plasticity in molecular recognition on the basis of x-ray structures.

Journal Article (Journal Article)

Calmodulin is the primary calcium-dependent signal transducer and regulator of a wide variety of essential cellular functions. The structure of calcium-calmodulin bound to the peptide corresponding to the calmodulin-binding domain of brain calmodulin-dependent protein kinase II alpha was determined to 2 angstrom resolution. A comparison to two other calcium-calmodulin structures reveals how the central helix unwinds in order to position the two domains optimally in the recognition of different target enzymes and clarifies the role of calcium in maintaining recognition-competent domain structures.

Full Text

Duke Authors

Cited Authors

  • Meador, WE; Means, AR; Quiocho, FA

Published Date

  • December 10, 1993

Published In

Volume / Issue

  • 262 / 5140

Start / End Page

  • 1718 - 1721

PubMed ID

  • 8259515

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.8259515


  • eng

Conference Location

  • United States