Calmodulin: a prototypical calcium sensor.
Journal Article (Journal Article;Review)
Calmodulin is the best studied and prototypical example of the E-F-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, at the cellular level, by directing its subcellular distribution. Second, at the molecular level, by promoting different modes of association with many target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. The calmodulin-dependent regulation of protein kinases illustrates the potential mechanisms by which Ca2+-sensing proteins can recognize and generate affinity and specificity for effectors in a Ca2+-dependent manner.
Full Text
Duke Authors
Cited Authors
- Chin, D; Means, AR
Published Date
- August 2000
Published In
Volume / Issue
- 10 / 8
Start / End Page
- 322 - 328
PubMed ID
- 10884684
International Standard Serial Number (ISSN)
- 0962-8924
Digital Object Identifier (DOI)
- 10.1016/s0962-8924(00)01800-6
Language
- eng
Conference Location
- England