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Calmodulin: a prototypical calcium sensor.

Publication ,  Journal Article
Chin, D; Means, AR
Published in: Trends Cell Biol
August 2000

Calmodulin is the best studied and prototypical example of the E-F-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, at the cellular level, by directing its subcellular distribution. Second, at the molecular level, by promoting different modes of association with many target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. The calmodulin-dependent regulation of protein kinases illustrates the potential mechanisms by which Ca2+-sensing proteins can recognize and generate affinity and specificity for effectors in a Ca2+-dependent manner.

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Published In

Trends Cell Biol

DOI

ISSN

0962-8924

Publication Date

August 2000

Volume

10

Issue

8

Start / End Page

322 / 328

Location

England

Related Subject Headings

  • Signal Transduction
  • Protein Conformation
  • Molecular Sequence Data
  • Humans
  • Developmental Biology
  • Calmodulin
  • Calcium
  • Biological Transport
  • Animals
  • Amino Acid Sequence
 

Citation

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Chin, D., & Means, A. R. (2000). Calmodulin: a prototypical calcium sensor. Trends Cell Biol, 10(8), 322–328. https://doi.org/10.1016/s0962-8924(00)01800-6
Chin, D., and A. R. Means. “Calmodulin: a prototypical calcium sensor.Trends Cell Biol 10, no. 8 (August 2000): 322–28. https://doi.org/10.1016/s0962-8924(00)01800-6.
Chin D, Means AR. Calmodulin: a prototypical calcium sensor. Trends Cell Biol. 2000 Aug;10(8):322–8.
Chin, D., and A. R. Means. “Calmodulin: a prototypical calcium sensor.Trends Cell Biol, vol. 10, no. 8, Aug. 2000, pp. 322–28. Pubmed, doi:10.1016/s0962-8924(00)01800-6.
Chin D, Means AR. Calmodulin: a prototypical calcium sensor. Trends Cell Biol. 2000 Aug;10(8):322–328.
Journal cover image

Published In

Trends Cell Biol

DOI

ISSN

0962-8924

Publication Date

August 2000

Volume

10

Issue

8

Start / End Page

322 / 328

Location

England

Related Subject Headings

  • Signal Transduction
  • Protein Conformation
  • Molecular Sequence Data
  • Humans
  • Developmental Biology
  • Calmodulin
  • Calcium
  • Biological Transport
  • Animals
  • Amino Acid Sequence