Calmodulin: a prototypical calcium sensor.

Journal Article (Journal Article;Review)

Calmodulin is the best studied and prototypical example of the E-F-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct ways. First, at the cellular level, by directing its subcellular distribution. Second, at the molecular level, by promoting different modes of association with many target proteins. Third, by directing a variety of conformational states in calmodulin that result in target-specific activation. The calmodulin-dependent regulation of protein kinases illustrates the potential mechanisms by which Ca2+-sensing proteins can recognize and generate affinity and specificity for effectors in a Ca2+-dependent manner.

Full Text

Duke Authors

Cited Authors

  • Chin, D; Means, AR

Published Date

  • August 2000

Published In

Volume / Issue

  • 10 / 8

Start / End Page

  • 322 - 328

PubMed ID

  • 10884684

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(00)01800-6


  • eng

Conference Location

  • England