Calmodulin and the cell cycle: involvement in regulation of cell-cycle progression.


Journal Article

Calmodulin levels are elevated twofold at late G1 and/or early S phases during the growth cycle of CHO-K1 cells. These levels are maintained throughout the remainder of the cell cycle unit cytokinesis. The G1 daughter cells then contain half the intracellular calmodulin level found prior to cell division. Elevation of calmodulin at the G1-S boundary is independent of the length of G1, and the increase in calmodulin appears to be related to progression into S phase. The importance of calmodulin for G1-S progression is suggested by the ability of the anticalmodulin drug W13 to elicit specific and reversible progression delays into and through S phase.

Full Text

Duke Authors

Cited Authors

  • Chafouleas, JG; Bolton, WE; Hidaka, H; Boyd, AE; Means, AR

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 28 / 1

Start / End Page

  • 41 - 50

PubMed ID

  • 7066986

Pubmed Central ID

  • 7066986

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(82)90373-7


  • eng

Conference Location

  • United States