Skip to main content
Journal cover image

Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.

Publication ,  Journal Article
Wu, JY; Gonzalez-Robayna, IJ; Richards, JS; Means, AR
Published in: Endocrinology
December 2000

Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) is a serine/threonine protein kinase with limited tissue distribution. CaMKIV is highly expressed in the testis, where it is found in transcriptionally inactive elongating spermatids. We have recently generated mice deficient in CaMKIV. In the absence of CaMKIV, the exchange of sperm nuclear basic proteins in male spermatids is impaired, resulting in male infertility secondary to defective spermiogenesis. The involvement of CaMKIV in female fertility has not been addressed. Here we report that female fertility is markedly reduced in CaMKIV-deficient mice due to impaired follicular development and ovulation. CaMKIV is expressed in the ovary, where it is localized in granulosa cells. We further find that in cultured granulosa cells, CaMKIV expression and subcellular localization are hormonally regulated. As granulosa cells differentiate, CaMKIV levels decrease and the kinase translocates from the nucleus into the cytoplasm. Our results demonstrate a critical role for CaMKIV in female reproduction and point to a potential function in granulosa cell differentiation.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

December 2000

Volume

141

Issue

12

Start / End Page

4777 / 4783

Location

United States

Related Subject Headings

  • Superovulation
  • Ovulation
  • Ovary
  • Ovarian Follicle
  • Mice, Inbred C57BL
  • Mice
  • Luteinizing Hormone
  • Infertility, Female
  • Immunohistochemistry
  • Granulosa Cells
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wu, J. Y., Gonzalez-Robayna, I. J., Richards, J. S., & Means, A. R. (2000). Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. Endocrinology, 141(12), 4777–4783. https://doi.org/10.1210/endo.141.12.7826
Wu, J. Y., I. J. Gonzalez-Robayna, J. S. Richards, and A. R. Means. “Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.Endocrinology 141, no. 12 (December 2000): 4777–83. https://doi.org/10.1210/endo.141.12.7826.
Wu JY, Gonzalez-Robayna IJ, Richards JS, Means AR. Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. Endocrinology. 2000 Dec;141(12):4777–83.
Wu, J. Y., et al. “Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV.Endocrinology, vol. 141, no. 12, Dec. 2000, pp. 4777–83. Pubmed, doi:10.1210/endo.141.12.7826.
Wu JY, Gonzalez-Robayna IJ, Richards JS, Means AR. Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. Endocrinology. 2000 Dec;141(12):4777–4783.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

December 2000

Volume

141

Issue

12

Start / End Page

4777 / 4783

Location

United States

Related Subject Headings

  • Superovulation
  • Ovulation
  • Ovary
  • Ovarian Follicle
  • Mice, Inbred C57BL
  • Mice
  • Luteinizing Hormone
  • Infertility, Female
  • Immunohistochemistry
  • Granulosa Cells