Ca2+-dependent regulation of cyclic-AMP phosphodiesterase by parvalbumin.

Journal Article

Carp parvalbumin has been shown to activate rat brain phosphodiesterase in a Ca2+-dependent manner. The concentration of Ca2+ required for half-maximal stimulation is 1.4 X 10(-7) M, whereas rat testis Ca2+-dependent regulator (CDR) of phosphodiesterase required 1.2 X 10(-6) M Ca2+. The difference in the slopes of the two curves demonstrated that the activation induced by parvalbumin was not the result of a small contamination by CDR. In addition, it has been shown that Ca2+ binding to parvalbumin parallels its activation of phosphodiesterase. These data suggest that Ca2+ must bind to a single specific metal binding site before phosphodiesterase can be fully activated.

Full Text

Duke Authors

Cited Authors

  • Potter, JD; Dedman, JR; Means, AR

Published Date

  • August 25, 1977

Published In

Volume / Issue

  • 252 / 16

Start / End Page

  • 5609 - 5611

PubMed ID

  • 195956

International Standard Serial Number (ISSN)

  • 0021-9258

Language

  • eng

Conference Location

  • United States