Calmodulin is involved in regulation of cell proliferation.

Published

Journal Article

A chicken calmodulin (CaM) gene has been expressed in mouse C127 cells using a bovine papilloma virus (BPV)-based vector (BPV-CM). The vector-borne genes produce a mature mRNA of the expected size that is present on cytoplasmic polyribosomes. In clonal cell lines transformed by BPV-CM, expression of the CaM gene produced CaM levels 2- to 4-fold above those observed in cells transformed by BPV alone. Increased intracellular CaM caused a reduction of cell cycle length that is solely due to a reduction in the length of the G1 phase. A comparison of six cell lines revealed a linear relationship between the intracellular CaM concentration and the rate of G1 progression. These data provide the first evidence that specific elevation of CaM levels directly affects the rate of cell proliferation.

Full Text

Duke Authors

Cited Authors

  • Rasmussen, CD; Means, AR

Published Date

  • December 1987

Published In

Volume / Issue

  • 6 / 13

Start / End Page

  • 3961 - 3968

PubMed ID

  • 2832147

Pubmed Central ID

  • 2832147

Electronic International Standard Serial Number (EISSN)

  • 1460-2075

International Standard Serial Number (ISSN)

  • 0261-4189

Digital Object Identifier (DOI)

  • 10.1002/j.1460-2075.1987.tb02738.x

Language

  • eng