Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.
Journal Article
Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.
Full Text
Duke Authors
Cited Authors
- Chafouleas, JG; Bolton, WE; Means, AR
Published Date
- June 22, 1984
Published In
Volume / Issue
- 224 / 4655
Start / End Page
- 1346 - 1348
PubMed ID
- 6203171
Pubmed Central ID
- 6203171
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.6203171
Language
- eng
Conference Location
- United States