Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.

Journal Article

Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.

Full Text

Duke Authors

Cited Authors

  • Chafouleas, JG; Bolton, WE; Means, AR

Published Date

  • June 22, 1984

Published In

Volume / Issue

  • 224 / 4655

Start / End Page

  • 1346 - 1348

PubMed ID

  • 6203171

Pubmed Central ID

  • 6203171

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6203171

Language

  • eng

Conference Location

  • United States