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Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.

Publication ,  Journal Article
Pan, F; Means, AR; Liu, JO
Published in: EMBO J
June 15, 2005

Calcium signaling is critical for activation of T lymphocytes and has been proposed to be transduced through multiple calmodulin target proteins. Whereas the calcineurin-NFAT signaling module is critical for all mammalian T cells, the role of calmodulin-dependent kinase IV (CaMKIV) in mouse naïve CD4+ T-cell activation remains enigmatic. We have applied lentivius-mediated RNA interference of CaMKIV to human T cells and found that knockdown of CaMKIV abrogates T-cell receptor-mediated transcription of the IL-2 gene. We demonstrate that CaMKIV directly phosphorylates Cabin1, a transcriptional corepressor for myocyte enhancer factor 2, creating a docking site for 14-3-3, which causes its nuclear export. CaMKIV-mediated nuclear export of Cabin1 is likely to account for a significant part of the requirement of CaMKIV during human T-cell activation.

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Published In

EMBO J

DOI

ISSN

0261-4189

Publication Date

June 15, 2005

Volume

24

Issue

12

Start / End Page

2104 / 2113

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Protein Transport
  • Phosphorylation
  • Phosphoproteins
  • Myogenic Regulatory Factors
  • MEF2 Transcription Factors
  • Lymphocyte Activation
 

Citation

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Pan, F., Means, A. R., & Liu, J. O. (2005). Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. EMBO J, 24(12), 2104–2113. https://doi.org/10.1038/sj.emboj.7600685
Pan, Fan, Anthony R. Means, and Jun O. Liu. “Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.EMBO J 24, no. 12 (June 15, 2005): 2104–13. https://doi.org/10.1038/sj.emboj.7600685.
Pan, Fan, et al. “Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation.EMBO J, vol. 24, no. 12, June 2005, pp. 2104–13. Pubmed, doi:10.1038/sj.emboj.7600685.

Published In

EMBO J

DOI

ISSN

0261-4189

Publication Date

June 15, 2005

Volume

24

Issue

12

Start / End Page

2104 / 2113

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Transcription Factors
  • T-Lymphocytes
  • Receptors, Antigen, T-Cell
  • Protein Transport
  • Phosphorylation
  • Phosphoproteins
  • Myogenic Regulatory Factors
  • MEF2 Transcription Factors
  • Lymphocyte Activation