The prognostic significance of CA 125 half-life in patients with ovarian cancer who have received primary chemotherapy after surgical cytoreduction.


Journal Article

Fifty-four patients with advanced epithelial ovarian cancer were monitored with serial serum CA 125 levels after surgical cytoreduction and during multi-agent chemotherapy with cisplatin-containing regimens. CA 125 half-life of less than 20 days was associated with prolonged overall survival (p less than 0.015). In those patients who eventually were found to be disease-free at surgical surveillance procedures, normalization of serum CA 125 levels to less than 35 U/ml within 65 days of primary operation also suggested an improved survival (p less than 0.059).

Full Text

Duke Authors

Cited Authors

  • Hunter, VJ; Daly, L; Helms, M; Soper, JT; Berchuck, A; Clarke-Pearson, DL; Bast, RC

Published Date

  • October 1990

Published In

Volume / Issue

  • 163 / 4 Pt 1

Start / End Page

  • 1164 - 1167

PubMed ID

  • 2171337

Pubmed Central ID

  • 2171337

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/0002-9378(90)90680-6


  • eng

Conference Location

  • United States