Epidermal growth factor receptor expression in normal and malignant endometrium.

Published

Journal Article

Epidermal growth factor receptor expression in fresh-frozen uterine tissues was studied with the use of monoclonal antibody 528, which recognizes an epitope on the external domain of the epidermal growth factor receptor. Immunohistochemically detectable epidermal growth factor receptor was seen in all uterine cell types in 19 of 20 normal uteri. Staining of endometrial glands and endometrial stromal cells was consistently greater than that of myometrium, and no variation in intensity or distribution of staining was seen during the menstrual cycle. Immunohistochemically detectable epidermal growth factor receptor was found less frequently in endometrial adenocarcinomas than in normal endometrium (p less than 0.01). Thirteen of 40 endometrial adenocarcinomas (32.5%) did not express detectable receptor. Epidermal growth factor receptor expression did not correlate with histologic grade, depth of myometrial invasion, estrogen-progesterone receptor status, the presence of extrauterine metastases, or the development of recurrent disease.

Full Text

Duke Authors

Cited Authors

  • Berchuck, A; Soisson, AP; Olt, GJ; Soper, JT; Clarke-Pearson, DL; Bast, RC; McCarty, KS

Published Date

  • November 1989

Published In

Volume / Issue

  • 161 / 5

Start / End Page

  • 1247 - 1252

PubMed ID

  • 2480065

Pubmed Central ID

  • 2480065

International Standard Serial Number (ISSN)

  • 0002-9378

Digital Object Identifier (DOI)

  • 10.1016/0002-9378(89)90676-5

Language

  • eng

Conference Location

  • United States