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The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer.

Publication ,  Journal Article
Rodriguez, GC; Clarke-Pearson, DL; Soper, JT; Berchuck, A; Synan, I; Dodge, RK
Published in: Obstet Gynecol
March 1994

OBJECTIVE: To determine the association between pretreatment platelet count and survival in women with stage IB cervical cancer. METHODS: Clinical records were reviewed for 219 women with stage IB cervical cancer treated by radical hysterectomy from 1971-1984. Univariate and multivariate analyses were performed to identify clinicopathologic variables associated with poor survival. Survival as a function of the preoperative platelet count was analyzed further and corrected for known prognostic factors. RESULTS: The cumulative 5-year survival of women with a preoperative platelet count greater than 300,000/microL (n = 85) was 65%, as compared to 84% for a count equal to or less than 300,000/microL (n = 134) (P = .004). Univariate Cox regression analysis revealed non-white race, large lesion size (greater than 4 cm), platelet count greater than 300,000/microL, and the presence of nodal metastases to be factors related to poor prognosis. A comparison of patients with platelet counts of 300,000/microL or less and patients with platelet counts greater than 300,000/microL revealed no difference with regard to race, nodal metastases, and median age. However, a larger percentage of women with a platelet count greater than 300,000/microL had large lesion size (29 of 60, versus 32 of 114 with a count of 300,000/microL or less). In a multivariate analysis, after adjusting for age, race, the presence of nodal metastases, and lesion size, high platelet count was still associated with poor prognosis (P = .04). CONCLUSION: An elevated platelet count is an independent prognostic factor for poor survival in patients with early-stage cervical cancer.

Duke Scholars

Published In

Obstet Gynecol

ISSN

0029-7844

Publication Date

March 1994

Volume

83

Issue

3

Start / End Page

445 / 448

Location

United States

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Thrombocytosis
  • Survival Rate
  • Regression Analysis
  • Prognosis
  • Obstetrics & Reproductive Medicine
  • Neoplasm Staging
  • Multivariate Analysis
  • Humans
  • Follow-Up Studies
 

Citation

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Rodriguez, G. C., Clarke-Pearson, D. L., Soper, J. T., Berchuck, A., Synan, I., & Dodge, R. K. (1994). The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer. Obstet Gynecol, 83(3), 445–448.
Rodriguez, G. C., D. L. Clarke-Pearson, J. T. Soper, A. Berchuck, I. Synan, and R. K. Dodge. “The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer.Obstet Gynecol 83, no. 3 (March 1994): 445–48.
Rodriguez GC, Clarke-Pearson DL, Soper JT, Berchuck A, Synan I, Dodge RK. The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer. Obstet Gynecol. 1994 Mar;83(3):445–8.
Rodriguez, G. C., et al. “The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer.Obstet Gynecol, vol. 83, no. 3, Mar. 1994, pp. 445–48.
Rodriguez GC, Clarke-Pearson DL, Soper JT, Berchuck A, Synan I, Dodge RK. The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer. Obstet Gynecol. 1994 Mar;83(3):445–448.
Journal cover image

Published In

Obstet Gynecol

ISSN

0029-7844

Publication Date

March 1994

Volume

83

Issue

3

Start / End Page

445 / 448

Location

United States

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Thrombocytosis
  • Survival Rate
  • Regression Analysis
  • Prognosis
  • Obstetrics & Reproductive Medicine
  • Neoplasm Staging
  • Multivariate Analysis
  • Humans
  • Follow-Up Studies