Growth regulation and transformation of ovarian epithelium.


Journal Article (Review)

The discovery of peptide growth factors and cancer-causing genes (oncogenes and tumor-suppressor genes) has provided us with the exciting opportunity to begin to understand the molecular pathology of human ovarian cancer. Activation of several genes, including HER-2/neu, myc, ras, and p53 have been described in some ovarian cancers. In addition, some protooncogenes such as the epidermal growth factor receptor (erbB) and the M-CSF receptor (fms) are expressed along with the respective ligands (peptide growth factors) in some ovarian cancers. Although the studies reviewed in this paper represent a promising beginning, we remain far from a comprehensive understanding of growth regulation and transformation of human ovarian epithelium.

Full Text

Duke Authors

Cited Authors

  • Berchuck, A; Kohler, MF; Boente, MP; Rodriguez, GC; Whitaker, RS; Bast, RC

Published Date

  • January 15, 1993

Published In

Volume / Issue

  • 71 / 2 Suppl

Start / End Page

  • 545 - 551

PubMed ID

  • 8420675

Pubmed Central ID

  • 8420675

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/cncr.2820710209


  • eng

Conference Location

  • United States