Combinations of multiple serum markers are superior to individual assays for discriminating malignant from benign pelvic masses.

Journal Article (Clinical Trial;Journal Article)

To determine whether measurement of the levels of multiple tumor markers in the preoperative serum of women presenting with a pelvic mass distinguished benign from malignant disease better than the assay of CA 125 alone, sera from 429 patients, 192 of whom had malignant histology, were assayed for 8 different markers: CA 125, macrophage colony-stimulating factor, OVX1, lipid-associated sialic acid (LASA), CA15-3, CA72-4, CA19-9, and CA54/61. The sensitivity and specificity of CA 125 alone (> 35 U/ml) was 78.1 and 76.8%, respectively. A panel consisting of CA 125, OVX1, LASA, CA15-3, and CA72-4 had a sensitivity of 83.3% and specificity of 84.0% when two or more markers were elevated. Using the concentrations of these five markers, logistic regression analysis had a sensitivity of 85.4% and a specificity of 83.1%. Considering the values of markers in different sequences, classification and regression tree analysis substantially improved the sensitivity to 90.6% and the specificity to 93.2%. When applied in clinical practice this approach could improve the management of women presenting with a pelvic mass and may also have application in screening for ovarian cancer.

Full Text

Duke Authors

Cited Authors

  • Woolas, RP; Conaway, MR; Xu, F; Jacobs, IJ; Yu, Y; Daly, L; Davies, AP; O'Briant, K; Berchuck, A; Soper, JT

Published Date

  • October 1995

Published In

Volume / Issue

  • 59 / 1

Start / End Page

  • 111 - 116

PubMed ID

  • 7557595

International Standard Serial Number (ISSN)

  • 0090-8258

Digital Object Identifier (DOI)

  • 10.1006/gyno.1995.1276


  • eng

Conference Location

  • United States