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Cell cycle control of BRCA2.

Publication ,  Journal Article
Vaughn, JP; Cirisano, FD; Huper, G; Berchuck, A; Futreal, PA; Marks, JR; Iglehart, JD
Published in: Cancer Res
October 15, 1996

Identifying the conditions and kinetics of the induction of BRCA2 gene expression may implicate roles for the function of the tumor suppressor gene. In this study, expression of BRCA2 mRNA is shown to be regulated by the cell cycle and associated with proliferation in normal and tumor-derived breast epithelial cells. Cells arrested in G(0) or early G1 contained low levels of BRCA2 mRNA. After release into a proliferating state, cells produced maximum levels of BRCA2 mRNA in late G1 and the S-phase. Similar cell cycle control of BRCA2 was observed in fractions of exponentially growing cells isolated by centrifugal elutriation. Expression of BRCA2 was shown to be independent of bulk DNA synthesis. In addition, the kinetics of BRCA2 mRNA up-regulation appeared to be similar to those of BRCA1, suggesting that the two genes could be commonly controlled. These results imply that these two tumor suppressor genes are utilized during growth and may have a protective role in cellular proliferation.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

October 15, 1996

Volume

56

Issue

20

Start / End Page

4590 / 4594

Location

United States

Related Subject Headings

  • Transcription Factors
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Lovastatin
  • Humans
  • Histones
  • Gene Expression Regulation, Neoplastic
  • Female
  • Enzyme Inhibitors
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vaughn, J. P., Cirisano, F. D., Huper, G., Berchuck, A., Futreal, P. A., Marks, J. R., & Iglehart, J. D. (1996). Cell cycle control of BRCA2. Cancer Res, 56(20), 4590–4594.
Vaughn, J. P., F. D. Cirisano, G. Huper, A. Berchuck, P. A. Futreal, J. R. Marks, and J. D. Iglehart. “Cell cycle control of BRCA2.Cancer Res 56, no. 20 (October 15, 1996): 4590–94.
Vaughn JP, Cirisano FD, Huper G, Berchuck A, Futreal PA, Marks JR, et al. Cell cycle control of BRCA2. Cancer Res. 1996 Oct 15;56(20):4590–4.
Vaughn, J. P., et al. “Cell cycle control of BRCA2.Cancer Res, vol. 56, no. 20, Oct. 1996, pp. 4590–94.
Vaughn JP, Cirisano FD, Huper G, Berchuck A, Futreal PA, Marks JR, Iglehart JD. Cell cycle control of BRCA2. Cancer Res. 1996 Oct 15;56(20):4590–4594.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

October 15, 1996

Volume

56

Issue

20

Start / End Page

4590 / 4594

Location

United States

Related Subject Headings

  • Transcription Factors
  • RNA, Messenger
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
  • Lovastatin
  • Humans
  • Histones
  • Gene Expression Regulation, Neoplastic
  • Female
  • Enzyme Inhibitors