Skip to main content
Journal cover image

Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization.

Publication ,  Journal Article
Packenham, JP; du Manoir, S; Schrock, E; Risinger, JI; Dixon, D; Denz, DN; Evans, JA; Berchuck, A; Barrett, JC; Devereux, TR; Ried, T
Published in: Mol Carcinog
August 1997

Uterine leiomyomas are the most prevalent tumor type in women of reproductive age and are the most common reason for hysterectomies. Although uterine leiomyomas are considered to be benign, they are a major public health concern for women. In contrast, leiomyosarcomas are rare but highly malignant uterine tumors. They may arise in uteri with preexisting leiomyomas and histologically sometimes resemble leiomyomas, thus causing controversy about whether leiomyosarcomas arise within leiomyomas. In this study, we used comparative genomic hybridization (CGH) to identify genetic alterations unique to each tumor type and alterations that are common between the two tumors. We analyzed 14 cases of uterine leiomyomas and eight cases of uterine leiomyosarcomas. Only two of the 14 leiomyomas exhibited genetic alterations, and those were restricted to gains on chromosomes 14 and 19 and losses on chromosomes 1 and 4. In addition, 68 leiomyomas were examined for loss of heterozygosity on chromosomes 1 and 4, and only three tumors exhibited any losses. In contrast, all eight leiomyosarcomas showed gains and losses of DNA by CGH, and in many cases multiple changes were observed. The most commonly observed genetic aberration, occurring in five tumors, was gains on both arms of chromosome 1, suggesting that this chromosome contains loci involved in the development of leiomyosarcoma. Our results do not provide evidence for the progression from benign leiomyoma to malignant leiomyosarcoma. Moreover, the large number of random chromosomal alterations in the leiomyosarcomas suggests that increased genetic instability plays a role in the formation of these tumors.

Duke Scholars

Published In

Mol Carcinog

DOI

ISSN

0899-1987

Publication Date

August 1997

Volume

19

Issue

4

Start / End Page

273 / 279

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Oncology & Carcinogenesis
  • Nucleic Acid Hybridization
  • Leiomyosarcoma
  • Leiomyoma
  • Humans
  • Gene Deletion
  • Female
  • DNA, Neoplasm
  • Chromosomes, Human, Pair 4
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Packenham, J. P., du Manoir, S., Schrock, E., Risinger, J. I., Dixon, D., Denz, D. N., … Ried, T. (1997). Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. Mol Carcinog, 19(4), 273–279. https://doi.org/10.1002/(sici)1098-2744(199708)19:4<273::aid-mc9>3.0.co;2-d
Packenham, J. P., S. du Manoir, E. Schrock, J. I. Risinger, D. Dixon, D. N. Denz, J. A. Evans, et al. “Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization.Mol Carcinog 19, no. 4 (August 1997): 273–79. https://doi.org/10.1002/(sici)1098-2744(199708)19:4<273::aid-mc9>3.0.co;2-d.
Packenham JP, du Manoir S, Schrock E, Risinger JI, Dixon D, Denz DN, et al. Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. Mol Carcinog. 1997 Aug;19(4):273–9.
Packenham, J. P., et al. “Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization.Mol Carcinog, vol. 19, no. 4, Aug. 1997, pp. 273–79. Pubmed, doi:10.1002/(sici)1098-2744(199708)19:4<273::aid-mc9>3.0.co;2-d.
Packenham JP, du Manoir S, Schrock E, Risinger JI, Dixon D, Denz DN, Evans JA, Berchuck A, Barrett JC, Devereux TR, Ried T. Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. Mol Carcinog. 1997 Aug;19(4):273–279.
Journal cover image

Published In

Mol Carcinog

DOI

ISSN

0899-1987

Publication Date

August 1997

Volume

19

Issue

4

Start / End Page

273 / 279

Location

United States

Related Subject Headings

  • Uterine Neoplasms
  • Oncology & Carcinogenesis
  • Nucleic Acid Hybridization
  • Leiomyosarcoma
  • Leiomyoma
  • Humans
  • Gene Deletion
  • Female
  • DNA, Neoplasm
  • Chromosomes, Human, Pair 4