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Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer.

Publication ,  Journal Article
Olt, G; Soper, J; Ramakrishnan, S; Xu, F; Berchuck, A; Clarke-Pearson, D; Dodge, R; Bast, RC
Published in: Am J Obstet Gynecol
April 1996

OBJECTIVE: Our purpose was to examine the relationship between preoperative serum levels of macrophage colony-stimulating factor, alone and in combination with CA 125, and the presence of prognostic clinicopathologic factors and subclinical metastases in women with endometrial cancer. STUDY DESIGN: Ninety-two women who underwent primary exploration for endometrial adenocarcinoma had preoperative serum samples evaluated for macrophage colony-stimulating factor and CA 125 levels. Multivariate analysis was used to determine the associations of surgicopathologic findings with macrophage colony-stimulating factor and CA 125 levels. Logistic regression analysis was used to identify factors associated with the risk of extrauterine disease. The association of macrophage colony-stimulating factor and CA 125 levels with stage, grade, and depth of myometrial invasion and histologic characteristics were analyzed with Fisher's two-tailed exact test. RESULTS: Elevated levels of macrophage colony-stimulating factor were not associated with depth of myometrial invasion, histologic grade, or histologic cell type; however, advanced stage (p = 0.02) and the presence of lymph node metastases (p = 0.04) were associated with elevated levels. Sensitivity and specificity of macrophage colony-stimulating factor for predicting extrauterine disease were 42% and 89%, respectively. If either an elevated macrophage colony-stimulating factor or an elevated CA 125 level was used to predict extrauterine disease, the sensitivity was increased to 67% but the specificity was decreased to 78%. Macrophage colony-stimulating factor elevations predicted lymph node metastases with a sensitivity of 50% and a specificity of 86%. A multivariate regression model showed CA 125 to be the most significant predictor of extrauterine disease; macrophage colony-stimulating factor also contributed prognostic information (p = 0.02). The sensitivity and specificity of the multivariate model for predicting extrauterine disease were 75% and 73%, respectively. CONCLUSION: Macrophage colony-stimulating factor and CA 125 are neither sensitive nor specific enough to be used as predictors of the presence or absence of extrauterine disease in patients with endometrial cancer.

Duke Scholars

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

April 1996

Volume

174

Issue

4

Start / End Page

1316 / 1319

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Regression Analysis
  • Preoperative Care
  • Obstetrics & Reproductive Medicine
  • Neoplasm Staging
  • Myometrium
  • Multivariate Analysis
  • Macrophage Colony-Stimulating Factor
  • Lymphatic Metastasis
  • Lymph Nodes
 

Citation

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Olt, G., Soper, J., Ramakrishnan, S., Xu, F., Berchuck, A., Clarke-Pearson, D., … Bast, R. C. (1996). Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer. Am J Obstet Gynecol, 174(4), 1316–1319. https://doi.org/10.1016/s0002-9378(96)70678-6
Olt, G., J. Soper, S. Ramakrishnan, F. Xu, A. Berchuck, D. Clarke-Pearson, R. Dodge, and R. C. Bast. “Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer.Am J Obstet Gynecol 174, no. 4 (April 1996): 1316–19. https://doi.org/10.1016/s0002-9378(96)70678-6.
Olt G, Soper J, Ramakrishnan S, Xu F, Berchuck A, Clarke-Pearson D, et al. Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer. Am J Obstet Gynecol. 1996 Apr;174(4):1316–9.
Olt, G., et al. “Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer.Am J Obstet Gynecol, vol. 174, no. 4, Apr. 1996, pp. 1316–19. Pubmed, doi:10.1016/s0002-9378(96)70678-6.
Olt G, Soper J, Ramakrishnan S, Xu F, Berchuck A, Clarke-Pearson D, Dodge R, Bast RC. Preoperative evaluation of macrophage colony-stimulating factor levels in patients with endometrial cancer. Am J Obstet Gynecol. 1996 Apr;174(4):1316–1319.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

April 1996

Volume

174

Issue

4

Start / End Page

1316 / 1319

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Regression Analysis
  • Preoperative Care
  • Obstetrics & Reproductive Medicine
  • Neoplasm Staging
  • Myometrium
  • Multivariate Analysis
  • Macrophage Colony-Stimulating Factor
  • Lymphatic Metastasis
  • Lymph Nodes