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Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.

Publication ,  Journal Article
Sasaki, H; Nishii, H; Takahashi, H; Tada, A; Furusato, M; Terashima, Y; Siegal, GP; Parker, SL; Kohler, MF; Berchuck, A
Published in: Cancer Res
April 15, 1993

Previous studies have demonstrated that some human endometrial carcinomas contain an activating point mutation in codon 12 of the Ki-ras protooncogene. To examine the hypothesis that this mutation may occur at an earlier stage of neoplastic progression in the endometrium, we analyzed 89 samples of premalignant endometrial hyperplasia and an additional 84 samples of endometrial carcinoma for point mutations of Ki-ras codon 12. Mutations were found in all three types of endometrial hyperplasia, simple, complex, and atypical, with no clear evidence of a differential distribution in any particular type. Furthermore, the overall incidence of Ki-ras mutations in the hyperplasia specimens (16%) was similar to the incidence detected in carcinomas (18%), indicating that ras mutation may represent an early event in a subset of endometrial carcinomas. When the tissue samples were segregated as to country of origin, the frequency of this mutation was approximately 2-fold higher in hyperplasia and carcinoma samples from Japan than from the United States, where the incidence, clinicopathological characteristics, and risk factors for endometrial carcinoma differ dramatically. There was no apparent correlation, however, between ras mutation and any pathological, histological, or clinical parameter examined, except survival. The presence of a ras mutation was inversely associated with death from disease, suggesting that this molecular feature may characterize a subset of endometrial carcinomas with a good prognosis.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

April 15, 1993

Volume

53

Issue

8

Start / End Page

1906 / 1910

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • Humans
  • Genes, ras
  • Female
  • Endometrial Neoplasms
  • Endometrial Hyperplasia
  • Codon
  • Carcinoma
 

Citation

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Chicago
ICMJE
MLA
NLM
Sasaki, H., Nishii, H., Takahashi, H., Tada, A., Furusato, M., Terashima, Y., … Berchuck, A. (1993). Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. Cancer Res, 53(8), 1906–1910.
Sasaki, H., H. Nishii, H. Takahashi, A. Tada, M. Furusato, Y. Terashima, G. P. Siegal, S. L. Parker, M. F. Kohler, and A. Berchuck. “Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.Cancer Res 53, no. 8 (April 15, 1993): 1906–10.
Sasaki H, Nishii H, Takahashi H, Tada A, Furusato M, Terashima Y, et al. Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. Cancer Res. 1993 Apr 15;53(8):1906–10.
Sasaki, H., et al. “Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma.Cancer Res, vol. 53, no. 8, Apr. 1993, pp. 1906–10.
Sasaki H, Nishii H, Takahashi H, Tada A, Furusato M, Terashima Y, Siegal GP, Parker SL, Kohler MF, Berchuck A. Mutation of the Ki-ras protooncogene in human endometrial hyperplasia and carcinoma. Cancer Res. 1993 Apr 15;53(8):1906–1910.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

April 15, 1993

Volume

53

Issue

8

Start / End Page

1906 / 1910

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • Humans
  • Genes, ras
  • Female
  • Endometrial Neoplasms
  • Endometrial Hyperplasia
  • Codon
  • Carcinoma