Mutations of the E-cadherin gene in human gynecologic cancers.
Journal Article (Journal Article)
Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial tumorigenesis, 135 carcinomas of the endometrium and ovary were examined for alterations in the E-cadherin coding region. Four mutations were identified: one somatic nonsense and one somatic missense mutation, both with retention of the wild-type alleles, and two missense mutations with somatic loss of heterozygosity in the tumour tissue. These data support the classification of E-cadherin as a human tumour suppressor gene.
Full Text
Duke Authors
Cited Authors
- Risinger, JI; Berchuck, A; Kohler, MF; Boyd, J
Published Date
- May 1994
Published In
Volume / Issue
- 7 / 1
Start / End Page
- 98 - 102
PubMed ID
- 8075649
International Standard Serial Number (ISSN)
- 1061-4036
Digital Object Identifier (DOI)
- 10.1038/ng0594-98
Language
- eng
Conference Location
- United States