Mutations of the E-cadherin gene in human gynecologic cancers.

Journal Article (Journal Article)

Expression of the E-cadherin cell adhesion molecule is reduced in several types of human carcinomas, and the protein serves as an invasion suppressor in vitro. To determine if mutations of the E-cadherin gene (on chromosome 16q22) contribute to epithelial tumorigenesis, 135 carcinomas of the endometrium and ovary were examined for alterations in the E-cadherin coding region. Four mutations were identified: one somatic nonsense and one somatic missense mutation, both with retention of the wild-type alleles, and two missense mutations with somatic loss of heterozygosity in the tumour tissue. These data support the classification of E-cadherin as a human tumour suppressor gene.

Full Text

Duke Authors

Cited Authors

  • Risinger, JI; Berchuck, A; Kohler, MF; Boyd, J

Published Date

  • May 1994

Published In

Volume / Issue

  • 7 / 1

Start / End Page

  • 98 - 102

PubMed ID

  • 8075649

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng0594-98


  • eng

Conference Location

  • United States