Bcl10 is not a target for frequent mutation in human carcinomas.

Published

Journal Article

The recently described Bcl10 gene has been suggested to be a major target gene for inactivation in a variety of human cancers. In order to further evaluate the role of this gene in human adult malignancies, we have analysed a series of carcinomas for mutations in the Bcl10 gene. We have screened a panel of 174 carcinoma samples in total, comprised of 47 breast, 36 epithelial ovarian, 36 endometrial, 12 cervical, 23 colorectal and 20 head/neck carcinomas, all unselected for grade or stage. This panel reflects, in part, tumours reported to have involvement of the 1p22 region of chromosome 1, the region harbouring the Bcl10 gene. No deleterious mutations were detected in any of the samples analysed, strongly suggesting that Bcl10 is not a common target for inactivation in adult malignancies and that BCL10 is not the gene targeted for frequent inactivation at 1p22.

Full Text

Duke Authors

Cited Authors

  • Lambers, AR; Gumbs, C; Ali, S; Marks, JR; Iglehart, JD; Berchuck, A; Futreal, PA

Published Date

  • July 1999

Published In

Volume / Issue

  • 80 / 10

Start / End Page

  • 1575 - 1576

PubMed ID

  • 10408401

Pubmed Central ID

  • 10408401

Electronic International Standard Serial Number (EISSN)

  • 1532-1827

International Standard Serial Number (ISSN)

  • 0007-0920

Digital Object Identifier (DOI)

  • 10.1038/sj.bjc.6690564

Language

  • eng