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Determination of proliferation index in advanced ovarian cancer using quantitative image analysis.

Publication ,  Journal Article
Jordan, PA; Kerns, BJ; Pence, JC; Kohler, MF; Bast, RC; Kinney, RB; Berchuck, A
Published in: Am J Clin Pathol
June 1993

It has been shown that the monoclonal antibody Ki-67 reacts with a nuclear antigen that is expressed only by proliferating cells. The feasibility of using image analysis to quantitate Ki-67 staining (proliferation index [PI]) of epithelial ovarian cancers was investigated. The PI was determined in 50 advanced-stage primary ovarian cancers. Frozen sections were immunostained with the Ki-67 monoclonal antibody, and the PI was calculated using static image analysis. Among 35 stage III ovarian carcinomas, the median PI was 8.9%, compared with 17.7% in 15 stage IV cancers (P = 0.06). There was no relationship between PI and histologic grade. The median survival time of 32 patients whose cancers had a high Ki-67 expression (> or = 7.5%) was 16.8 months, which differed significantly (P < 0.01) from the median survival of 31.5 months observed in patients whose tumors demonstrated low Ki-67 expression (< 7.5%). Quantitative image analysis of Ki-67-stained fresh-frozen ovarian cancers may provide useful prognostic information. Further studies are warranted to investigate the relationship between Ki-67 expression and other known clinicopathologic and genetic features of ovarian cancer.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

June 1993

Volume

99

Issue

6

Start / End Page

736 / 740

Location

England

Related Subject Headings

  • Time Factors
  • Survival Analysis
  • Prognosis
  • Pathology
  • Ovarian Neoplasms
  • Nuclear Proteins
  • Neoplasm Staging
  • Neoplasm Proteins
  • Mitotic Index
  • Kinetics
 

Citation

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ICMJE
MLA
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Jordan, P. A., Kerns, B. J., Pence, J. C., Kohler, M. F., Bast, R. C., Kinney, R. B., & Berchuck, A. (1993). Determination of proliferation index in advanced ovarian cancer using quantitative image analysis. Am J Clin Pathol, 99(6), 736–740. https://doi.org/10.1093/ajcp/99.6.736
Jordan, P. A., B. J. Kerns, J. C. Pence, M. F. Kohler, R. C. Bast, R. B. Kinney, and A. Berchuck. “Determination of proliferation index in advanced ovarian cancer using quantitative image analysis.Am J Clin Pathol 99, no. 6 (June 1993): 736–40. https://doi.org/10.1093/ajcp/99.6.736.
Jordan PA, Kerns BJ, Pence JC, Kohler MF, Bast RC, Kinney RB, et al. Determination of proliferation index in advanced ovarian cancer using quantitative image analysis. Am J Clin Pathol. 1993 Jun;99(6):736–40.
Jordan, P. A., et al. “Determination of proliferation index in advanced ovarian cancer using quantitative image analysis.Am J Clin Pathol, vol. 99, no. 6, June 1993, pp. 736–40. Pubmed, doi:10.1093/ajcp/99.6.736.
Jordan PA, Kerns BJ, Pence JC, Kohler MF, Bast RC, Kinney RB, Berchuck A. Determination of proliferation index in advanced ovarian cancer using quantitative image analysis. Am J Clin Pathol. 1993 Jun;99(6):736–740.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

June 1993

Volume

99

Issue

6

Start / End Page

736 / 740

Location

England

Related Subject Headings

  • Time Factors
  • Survival Analysis
  • Prognosis
  • Pathology
  • Ovarian Neoplasms
  • Nuclear Proteins
  • Neoplasm Staging
  • Neoplasm Proteins
  • Mitotic Index
  • Kinetics