Oncogenes in ovarian cancer.


Journal Article (Review)

The discovery of cancer-causing genes has provided us with the exciting opportunity to begin to understand the molecular pathology of ovarian cancer. Activation of several of these genes including HER-2/neu, myc, ras, and p53 has been described in some ovarian cancers (Table 2). In addition, some proto-oncogenes such as the EGF receptor (erbB) and the M-CSF receptor (fms) are expressed along with their respective ligands in some ovarian cancers. Finally, for every oncogene that has been studied in ovarian cancer, there are at least a half-dozen that remain unexplored. In the future, when we have a better understanding of the molecular pathology involved in the development of ovarian cancer, this may allow us to better diagnose and treat, and eventually prevent, ovarian cancer.

Full Text

Duke Authors

Cited Authors

  • Berchuck, A; Kohler, MF; Bast, RC

Published Date

  • August 1992

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 813 - 827

PubMed ID

  • 1500387

Pubmed Central ID

  • 1500387

International Standard Serial Number (ISSN)

  • 0889-8588


  • eng

Conference Location

  • United States