Oncogenes in ovarian cancer.
The discovery of cancer-causing genes has provided us with the exciting opportunity to begin to understand the molecular pathology of ovarian cancer. Activation of several of these genes including HER-2/neu, myc, ras, and p53 has been described in some ovarian cancers (Table 2). In addition, some proto-oncogenes such as the EGF receptor (erbB) and the M-CSF receptor (fms) are expressed along with their respective ligands in some ovarian cancers. Finally, for every oncogene that has been studied in ovarian cancer, there are at least a half-dozen that remain unexplored. In the future, when we have a better understanding of the molecular pathology involved in the development of ovarian cancer, this may allow us to better diagnose and treat, and eventually prevent, ovarian cancer.
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Related Subject Headings
- Protein-Tyrosine Kinases
- Ovarian Neoplasms
- Oncology & Carcinogenesis
- Oncogenes
- Humans
- Genes, Tumor Suppressor
- GTP-Binding Proteins
- Female
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
Citation
Published In
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Protein-Tyrosine Kinases
- Ovarian Neoplasms
- Oncology & Carcinogenesis
- Oncogenes
- Humans
- Genes, Tumor Suppressor
- GTP-Binding Proteins
- Female
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology