Promoter hypermethylation as an epigenetic component in Type I and Type II endometrial cancers.
Epigenetic mechanisms that result in aberrant gene expression are a prominent feature of many cancer types. One main epigenetic mechanism for gene silencing involves promoter hypermethylation. Type I and type II endometrial cancers exhibit differing clinical, histologic, and molecular genetic characteristics. We hypothesize that these differences also extend to epigenetic phenomena. Promoter methylation analysis of 11 genes in a panel of endometrial cancers supports this hypothesis. These initial data indicate that promoter hypermethylation events occur frequently in type 1 cancer and were not detected in type II cancers using this panel of loci. These data tend to support the hypothesis that type I and type II endometrial cancers will exhibit distinct patterns of gene silencing based on promoter hypermethylation events.
Duke Scholars
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- Promoter Regions, Genetic
- Humans
- General Science & Technology
- Female
- Endometrial Neoplasms
- DNA Methylation
- Cell Transformation, Neoplastic
Citation
Published In
DOI
ISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Promoter Regions, Genetic
- Humans
- General Science & Technology
- Female
- Endometrial Neoplasms
- DNA Methylation
- Cell Transformation, Neoplastic