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A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery.

Publication ,  Journal Article
Clarke-Pearson, DL; Synan, IS; Dodge, R; Soper, JT; Berchuck, A; Coleman, RE
Published in: Am J Obstet Gynecol
April 1993

OBJECTIVE: Our aim was to determine the relative efficacy and complications of low-dose heparin and intermittent pneumatic calf compression for the prevention of postoperative venous thrombosis in patients undergoing surgery for gynecologic malignancy. STUDY DESIGN: Randomized trial comparing 107 patients treated with low-dose heparin to 101 patients treated with intermittent pneumatic calf compression was performed. All patients were evaluated with iodine-125 fibrinogen scanning of the legs. Clinical and laboratory variables associated with bleeding complications were recorded prospectively. RESULTS: Venous thrombosis was diagnosed in seven patients receiving low-dose heparin and in four receiving intermittent pneumatic calf compression (p = 0.54). Low-dose heparin patients received more blood transfusions postoperatively (p = 0.02), had increased volume of retroperitoneal drainage (p = 0.02), and the activated partial thromboplastin time was more frequently prolonged (p = 0.001). CONCLUSIONS: Low-dose heparin and intermittent pneumatic calf compression provide similar reduction in reducing the incidence of postoperative venous thrombosis. However, low-dose heparin is more frequently associated with postoperative bleeding complications.

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Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

April 1993

Volume

168

Issue

4

Start / End Page

1146 / 1153

Location

United States

Related Subject Headings

  • Thrombosis
  • Risk Factors
  • Postoperative Complications
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Incidence
  • Humans
  • Heparin
  • Hemorrhage
  • Gravity Suits
 

Citation

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Clarke-Pearson, D. L., Synan, I. S., Dodge, R., Soper, J. T., Berchuck, A., & Coleman, R. E. (1993). A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery. Am J Obstet Gynecol, 168(4), 1146–1153. https://doi.org/10.1016/0002-9378(93)90360-u
Clarke-Pearson, D. L., I. S. Synan, R. Dodge, J. T. Soper, A. Berchuck, and R. E. Coleman. “A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery.Am J Obstet Gynecol 168, no. 4 (April 1993): 1146–53. https://doi.org/10.1016/0002-9378(93)90360-u.
Clarke-Pearson DL, Synan IS, Dodge R, Soper JT, Berchuck A, Coleman RE. A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery. Am J Obstet Gynecol. 1993 Apr;168(4):1146–53.
Clarke-Pearson, D. L., et al. “A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery.Am J Obstet Gynecol, vol. 168, no. 4, Apr. 1993, pp. 1146–53. Pubmed, doi:10.1016/0002-9378(93)90360-u.
Clarke-Pearson DL, Synan IS, Dodge R, Soper JT, Berchuck A, Coleman RE. A randomized trial of low-dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery. Am J Obstet Gynecol. 1993 Apr;168(4):1146–1153.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

ISSN

0002-9378

Publication Date

April 1993

Volume

168

Issue

4

Start / End Page

1146 / 1153

Location

United States

Related Subject Headings

  • Thrombosis
  • Risk Factors
  • Postoperative Complications
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Incidence
  • Humans
  • Heparin
  • Hemorrhage
  • Gravity Suits