Necrotizing fasciitis in irradiated tissue from diabetic women. A report of two cases.

Published

Journal Article

Two diabetic women with pelvic malignancies developed necrotizing fasciitis within the irradiation fields. Despite aggressive surgical and medical therapy, both died when their health became too unstable for them to tolerate further surgery to resect the residual infection. We attribute their poor outcome to several factors. First, postradiation tissue changes obscured the early clinical findings necessary for a prompt diagnosis and made the identification of adequate surgical margins difficult. Second, diabetic patients have increased susceptibility to this infection. Third, the cumulative effects of radiation, diabetes mellitus and other factors that are common in patients with gynecologic malignancy (advanced age, vascular disease, obesity) favor the development, progression and persistence of necrotizing fasciitis. Radiographic studies were helpful in defining the extent of the infection in one patient.

Full Text

Cited Authors

  • Livengood, CH; Soper, JT; Clarke-Pearson, DL; Addison, WA

Published Date

  • June 1991

Published In

Volume / Issue

  • 36 / 6

Start / End Page

  • 455 - 458

PubMed ID

  • 1865403

Pubmed Central ID

  • 1865403

International Standard Serial Number (ISSN)

  • 0024-7758

Language

  • eng

Conference Location

  • United States