Preferential motor reinnervation in the mouse: comparison of femoral nerve repair using a fibrin sealant or suture.

Journal Article

Previous studies in rat femoral nerve demonstrated that regenerating motor axons preferentially reinnervate a nerve branch to muscle as opposed to skin, a process that has been termed preferential motor reinnervation (PMR). This process has not been previously reported in the mouse, where the use of transgenic animals could be a powerful tool to study the basic mechanisms that determine accuracy of regenerating motor axons. In the mouse, we applied the same nerve repair (suture) and retrograde labeling strategies that successfully demonstrated PMR in the rat femoral nerve but surprisingly were unable to demonstrate PMR. However, if the mouse femoral nerve was repaired with a fibrin sealant, PMR was readily apparent, suggesting that PMR in the mouse is dependent on the method of nerve repair.

Full Text

Duke Authors

Cited Authors

  • Robinson, GA; Madison, RD

Published Date

  • August 2003

Published In

Volume / Issue

  • 28 / 2

Start / End Page

  • 227 - 231

PubMed ID

  • 12872328

International Standard Serial Number (ISSN)

  • 0148-639X

Digital Object Identifier (DOI)

  • 10.1002/mus.10422

Language

  • eng

Conference Location

  • United States